Most people with celiac disease are familiar with the standard celiac blood panel. It typically includes seven tests: Total IgA, TTG IgA, TTG IgG, DGP IgA, DGP IgG, and EMA IgA. Each of these tests has different levels of accuracy and specificity when it comes to diagnosing celiac disease.

TTG IgG Only Positive

When the TTG IgG is the only positive test in the celiac blood panel, and both the Total IgA and TTG IgA are normal, there’s only about a 3% chance that the issue is truly celiac disease.

Many people share their bloodwork results online and assume that a single positive TTG IgG means they have celiac disease. Unfortunately, that’s not accurate. An isolated TTG IgG result can be caused by other autoimmune conditions or unrelated immune responses.

A 2018 study found that isolated TTG IgG positivity rarely indicates true celiac disease and that confirmatory testing is essential. Sharing accurate information helps others avoid unnecessary dietary restrictions or misdiagnosis.

Read the study here.

Double Positive Diagnosis

In 2025, researchers identified a new and promising use for two of the same antibody tests we’ve used for years: TTG IgA and DGP IgG. When both of these tests are positive, they can confirm celiac disease with more than 92% accuracy — even without an endoscopy.

The study found that when both test results are more than ten times the upper limit of normal (for example, if the normal range goes up to 4, results of 41 or higher), the likelihood of celiac disease reaches 100%.

Read the 2025 study here.

Why This Matters

Celiac blood testing hasn’t changed much in the past decade, but how we use and interpret the results is evolving. Understanding the antibody patterns, their reliability, and when to trust them can make a big difference in accurate diagnosis and long-term management.

With better testing standards and continued research, we can shorten the diagnostic process, reduce false positives, and ensure that those living with celiac disease get the care they truly need.

Keywords: celiac disease, celiac blood testing, TTG IgA, TTG IgG, DGP IgG, EMA IgA, celiac diagnosis, gluten free, autoimmune testing, intestinal biopsy, endoscopy

Tags: Celiac Disease, Research, Gluten Free Living, Diagnosis, Clinical Studies, Antibody Testing, Health Education