TTG IGA Negative & Still Celiac?

Celiac disease is commonly found when a patient reports symptoms to their doctor. Simple blood tests are run. Most commonly the Tissue Transglutaminase IGA or TTG IGA test is done. The TTG IGA test often determines if further celiac testing is warranted. The reliance on the TTG IGA test to determine further celiac testing may be a bit overblown. I'll explain.

The Challenge of the Gluten Challenge

I have a gluten free diet that isn't ideal, but effective to help with my celiac. So, the drug companies have to make a good argument to me that their drug will help alleviate symptoms and prevent damage to my intestines in order for me to spend my hard earned money on their solution. This begs the question - can someone prove to me that their drug works without a gluten challenge?